Het-PDB Navi2 (PDB: 6D09)

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Ligands
Code	Name		Style	Show	Link
FOJ	3-{[(3r)-4-(difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-dioxo-2,3-dihydro-1h-1-benzothiophen-5-yl]oxy}-5-fluorobenzonitrile				PoSSuM

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Download interaction data: 6D09

Code :

6D09 PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Crystal structure of PT2440 bound to HIF2a-B*:ARNT-B* complex

Release Data :

2018-10-31

Compound :

mol_id	molecule	chains	synonym
1	Endothelial PAS domain-containing protein 1	A	EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2
	fragment: residues 239-350 mutation: R14E

mol_id	molecule	chains	synonym
2	Aryl hydrocarbon receptor nuclear translocator	B	ARNT protein,Class E basic helix-loop-helix protein 2,bHLHe2,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF1-beta
	fragment: residues 356-470 mutation: E13R

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: EPAS1, BHLHE73, HIF2A, MOP2, PASD2

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: ARNT, BHLHE2

Authors :

Du, X.

Keywords :

Hif2a, Pas B domain, ARNT, hypoxia inducible factor, EPAS1, TRANSCRIPTION

Exp. method :

X-RAY DIFFRACTION ( 1.8500 Å )

Citation :

Crystal structure of PT1940 bound to HIF2a-B*:ARNT-B* complex

Du, X.
To Be Published

PDB ID: 6D09