Het-PDB Navi2 (PDB: 6CZ4)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
FKY	2-{[(3r,4s)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1h-imidazol-4-yl)pyridine-3-carboxamide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 6CZ4

Code :

6CZ4 PDBj RCSB PDB PDBe

Header :

Transferase/Transferase Inhibitor

Title :

Structure of the PTK6 kinase domain bound to a type II inhibitor 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide

Release Data :

2018-06-20

Compound :

mol_id	molecule	chains	synonym
1	Protein-tyrosine kinase 6	A	Breast tumor kinase,Tyrosine-protein kinase BRK
	ec: 2.7.10.2

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: PTK6, BRK

Authors :

Gajiwala, K.S., Johnson, E., Cronin, C.N.

Keywords :

Protein kinase, PTK6, Transferase-Transferase Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.50 Å )

Citation :

Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.

Qiu, L.,Levine, K.,Gajiwala, K.S. et al.
(2018) PLoS ONE 13 : e0198374 - e0198374

PubMed: 29879184
DOI: 10.1371/journal.pone.0198374

Chain :

UniProt :

Q13882 (PTK6_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:12121988, PubMed:27480927, PubMed:27993680
	-

PDB ID: 6CZ4

Hetero Atom Contents

Structure summary

Reaction