Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
ACT Acetate ion
FLJ (3-fluoro-4-{[6-methyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone
K Potassium ion
Code : 6CZ3
Header : Transferase/Transferase Inhibitor
Title : Structure of the PTK6 kinase domain bound to a type I inhibitor (3-fluoro-4-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone
Release Data : 2018-06-20
Compound :
mol_id molecule chains synonym
1 Protein-tyrosine kinase 6 A Breast tumor kinase,Tyrosine-protein kinase BRK
ec: 2.7.10.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PTK6, BRK
Authors : Gajiwala, K.S., Johnson, E., Cronin, C.N.
Keywords : Protein kinase, PTK6, Transferase-Transferase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.

Qiu, L.,Levine, K.,Gajiwala, K.S.  et al.
(2018)  PLoS ONE  13 : e0198374 - e0198374

PubMed: 29879184
DOI: 10.1371/journal.pone.0198374

Chain : A
UniProt : Q13882 (PTK6_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.