PDB ID: 6CXS
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Structure summary
Code : | 6CXS PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||||||||||||||
Title : | Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-C]isoquinolin-5-yl)morpholine | ||||||||||||||||||||||||
Release Data : | 2019-04-17 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Wallace, B.D., Redinbo, M.R. | ||||||||||||||||||||||||
Keywords : | HYDROLASE-HYDROLASE-INHIBITOR complex, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.8000 Å ) | ||||||||||||||||||||||||
Citation : |
Targeted inhibition of gut bacterial beta-glucuronidase activity enhances anticancer drug efficacy.
Bhatt, A.P.,Pellock, S.J.,Biernat, K.A.
et al.
PubMed: 32170007 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | Q8XP19 (BGLR_CLOPE) | ||||||||
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Chain : | C, D |
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UniProt : | P0AEX9 (MALE_ECOLI) |
Reaction : | - |