Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
FJV 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-C]isoquinolin-5-yl)morpholine
Code : 6CXS
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-C]isoquinolin-5-yl)morpholine
Release Data : 2019-04-17
Compound :
mol_id molecule chains
1 Beta-glucuronidase A,B
mol_id molecule chains synonym
2 Maltose/maltodextrin-binding periplasmic protein C,D MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP
fragment: residues 27-392
Source :
mol_id organism_scientific expression_system
1 Clostridium perfringens (strain 13 / Type A)  (taxid:195102) Escherichia coli  (taxid:562)
strain: 13 / Type A
gene: bglR
mol_id organism_scientific expression_system
2 Escherichia coli  (taxid:83333) Escherichia coli  (taxid:562)
strain: K12
gene: malE, b4034, JW3994
Authors : Wallace, B.D., Redinbo, M.R.
Keywords : HYDROLASE-HYDROLASE-INHIBITOR complex, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.8000 Å )
Citation :

Precision Gut Bacterial Enzyme Inhibition Enhances Irinotecan Efficacy

Bhatt, A.P.,Pellock, S.J.,Walton, W.G.  et al.
To Be Published 

Chain : A, B
UniProt : Q8XP19 (No found in current UniProtKB/SwissProt)
Reaction : -
Chain : C, D
UniProt : P0AEX9 (MALE_ECOLI)
Reaction : -