Het-PDB Navi2 (PDB: 6CVY)

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Ligands
Code	Name	Link
FHD	3-methyl-N-[(pentyloxy)carbonyl]-L-valyl-(4r)-4-[(3-chloro-7-methoxyquinoxalin-2-yl)oxy]-N-[(1r,2s)-2-ethenyl-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-L-prolinamide	PoSSuM
GOL	Glycerol	PoSSuM
SO4	Sulfate ion	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
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Download interaction data: 6CVY

Code :

6CVY PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE Inhibitor

Title :

Crystal structure of HCV NS3/4A WT protease in complex with AJ-21 (MK-5172 linear analogue)

Release Data :

2018-08-08

Compound :

mol_id	molecule	chains
1	NS3 protease	A

Source :

mol_id	organism_scientific	expression_system
1	Hepacivirus C (taxid:11103)	Escherichia coli BL21(DE3) (taxid:469008)
	expression_system_strain: BL21(DE3) expression_system_vector_type: Plasmid expression_system_plasmid: pET-28a

Authors :

Matthew, A.N., Schiffer, C.A.

Keywords :

NS3/4a Protease, Hepatitis C virus, Drug Resistance, protease inhibitor, HYDROLASE-HYDROLASE Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.798 Å )

Citation :

Quinoxaline-Based Linear HCV NS3/4A Protease Inhibitors Exhibit Potent Activity against Drug Resistant Variants.

Rusere, L.N.,Matthew, A.N.,Lockbaum, G.J. et al.
(2018) ACS Med Chem Lett 9 : 691 - 696

Chain :

UniProt :

A0A0B4WYC6 (A0A0B4WYC6_9HEPC)

PDB ID: 6CVY