Het-PDB Navi2 (PDB: 6CUZ)

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Ligands
Code	Name		Style	Show	Link
NA	Sodium ion				PoSSuM
FEV	(2e)-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]pent-2-enoic acid				PoSSuM

Non-standard Residues
Code	Name	Show
LLP	(2s)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 6CUZ

Code :

6CUZ PDBj RCSB PDB PDBe

Header :

LYASE

Title :

Engineered TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3R)-ethylserine bound as the amino-acrylate

Release Data :

2018-09-26

Compound :

mol_id	molecule	chains
1	Tryptophan synthase beta chain 1	A,D
	ec: 4.2.1.20 mutation: I16V, E17G, L91P, F95L, L161A, V173E, F274L, T292S, V384A other_details: (2S,3R)-ethylserine bound as the amino-acrylate

mol_id	molecule	chains
2	Tryptophan synthase beta chain 1	B,C
	ec: 4.2.1.20 mutation: I16V, E17G, L91P, F95L, L161A, V173E, F274L, T292S, V384A other_details: holo

Source :

mol_id	organism_scientific	expression_system
1	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (taxid:186497)	Escherichia coli (taxid:469008)
	strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1 gene: trpB1, PF1706 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET-22b(+)

mol_id	organism_scientific	expression_system
2	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (taxid:186497)	Escherichia coli (taxid:469008)
	strain: ATCC 43587 / DSM 3638 / JCM 8422 / Vc1 gene: trpB1, PF1706 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET-22b(+)

Authors :

Scheele, R.A., Buller, A.R., Boville, C.E., Arnold, F.H.

Keywords :

amino-acrylate, (2S, 3R)-ethylserine, LYASE

Exp. method :

X-RAY DIFFRACTION ( 1.7500 Å )

Citation :

Engineered Biosynthesis of beta-Alkyl Tryptophan Analogues.

Boville, C.E.,Scheele, R.A.,Koch, P. et al.
(2018) Angew. Chem. Int. Ed. Engl. 57 : 14764 - 14768

Chain :

B, C

UniProt :

Q8U093 (TRPB1_PYRFU)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + L-tryptophan + H2O	4.2.1.20	-
	-	-
Cofactor:	Evidence:	Note:
pyridoxal 5'-phosphate	ECO:0000250	-

PDB ID: 6CUZ