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Ligands
Code Name Style Show Link
MN Manganese (II) ion
NA Sodium ion
XG4 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine
Non-standard Residues
Code Name Show
F74 8-chloro-2'-deoxyguanosine 5'-(dihydrogen phosphate)
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 6CUA   PDBj   RCSB PDB   PDBe
Header : Transferase, Lyase/DNA
Title : Structure of human DNA polymerase beta complexed with 8-ClG in the template base paired with incoming non-hydrolyzable GTP and MANGANESE
Release Data : 2019-03-27
Compound :
mol_id molecule chains
1 DNA polymerase beta A
ec: 2.7.7.7,4.2.99.-
mol_id molecule chains
2 DNA (5'-D(*CP*CP*GP*AP*CP*(CGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') T
mol_id molecule chains
3 DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3') P
mol_id molecule chains
4 DNA (5'-D(P*GP*TP*CP*GP*G)-3') D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: POLB
mol_id organism_scientific
2 Homo sapiens  (taxid:9606)
synthetic: yes
mol_id organism_scientific
3 Homo sapiens  (taxid:9606)
synthetic: yes
mol_id organism_scientific
4 Homo sapiens  (taxid:9606)
synthetic: yes
Authors : Koag, M.-C., Lee, S.
Keywords : DNA binding Protein, Transferase, Lyase-DNA complex
Exp. method : X-RAY DIFFRACTION ( 2.17 Å )
Citation :

Structure of human DNA polymerase beta complexed with 8-ClG in the template base paired with incoming non-hydrolyzable GTP and MANGANESE

Koag, M.-C.,Lee, S.
To Be Published 

Chain : A
UniProt : P06746 (DPOLB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 -
-
a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)- 4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-monophospho-2'- deoxyribonucleoside-DNA + H(+) - PubMed:9572863, PubMed:9614142
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2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+) 4.2.99.18 PubMed:9614142
-