Brand  (β version)

color scheme of protein:


interaction residue:

chain: Hide other chain(s)

Code Name Link
CL Chloride ion
DC 2'-deoxycytidine-5'-monophosphate
MG Magnesium ion
NA Sodium ion
F3C 2'-deoxy-5'-O-[(R)-{[(R)-[(R)-fluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]cytidine
FF4 2'-deoxy-5'-O-[(R)-{[(R)-[(S)-fluoro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]cytidine
Modified Residues
Code Name Link
2DA 2',3'-dideoxyadenosine-5'-monophosphate
Code : 6CTR
Header : transcription/dna
Title : Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHF (R & S isomers), beta, gamma dCTP analogue
Release Data : 2018-06-20
Compound :
mol_id molecule chains
mol_id molecule chains
2 DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(2DA))-3') P
mol_id molecule chains
3 DNA (5'-D(P*GP*TP*CP*GP*G)-3') D
mol_id molecule chains
4 DNA polymerase beta A
Source :
mol_id organism_scientific
1 Homo sapiens  (taxid:9606)
synthetic: yes
mol_id organism_scientific
2 Homo sapiens  (taxid:9606)
synthetic: yes
mol_id organism_scientific
3 Homo sapiens  (taxid:9606)
synthetic: yes
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: POLB
expression_system_strain: Tap56
expression_system_vector_type: Plasmid
expression_system_plasmid: pwl-11
Authors : Batra, V.K., Wilson, S.H.
Keywords : DNA Polymerase Beta, Conformational Change, enzyme mechanism, LFER, transcription-dna complex
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.

Batra, V.K.,Oertell, K.,Beard, W.A.  et al.
(2018)  Biochemistry  57 : 3934 - 3944

PubMed: 29874056
DOI: 10.1021/acs.biochem.8b00418

Chain : A
UniProt : P06746 (DPOLB_HUMAN)
Reaction : Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).