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Ligands
Code Name Style Show Link
COA Coenzyme a
FD7 N-(2,6-diethylphenyl)-N'-(N-ethylcarbamimidoyl)urea
MG Magnesium ion
GOL Glycerol
DMS Dimethyl sulfoxide
Non-standard Residues
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Code : 6CT5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/INHIBITOR
Title : PptT PAP(CoA) 8918 complex
Release Data : 2019-02-06
Compound :
mol_id molecule chains synonym
1 4'-phosphopantetheinyl transferase A,B Phosphopantetheinyl transferase PptT (CoA:apo-[ACP]pantetheinephosphotransferase) (CoA:apo-[acyl-carrier protein]pantetheinephosphotransferase)
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli BL21(DE3)  (taxid:469008)
gene: CRX58_05810, ERS124361_01504
expression_system_plasmid: pMCSG28
Authors : Mosior, J., Sacchettini, J., TB Structural Genomics Consortium (TBSGC)
Keywords : Inhibitor, complex, Structural Genomics, TB Structural Genomics Consortium, TBSGC, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.75934602056 Å )
Citation :

Opposing reactions in coenzyme A metabolism sensitizeMycobacterium tuberculosisto enzyme inhibition.

Ballinger, E.,Mosior, J.,Hartman, T.  et al.
(2019)  Science  363

PubMed: 30705156
DOI: 10.1126/science.aau8959

Chain : A, B
UniProt : A0A0T9N0I0
Reaction : -