Brand  (β version)

PDB ID: 6CT2

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Ligands
Code Name Style Show Link
FCV 3-fluoro-N'-[(2-fluorophenyl)sulfonyl]-5-(pyridin-2-yl)benzohydrazide PoSSuM
MG Magnesium ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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ALY N(6)-acetyllysine
Glycosylation
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Structure summary

Code : 6CT2   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/INHIBITOR
Title : MYST histone acetyltransferase KAT6A/B in complex with WM-1119
Release Data : 2018-08-01
Compound :
mol_id molecule chains synonym
1 Histone acetyltransferase KAT8 A Lysine acetyltransferase 8,MOZ,YBF2/SAS3,SAS2 and TIP60 protein 1,hMOF
ec: 2.3.1.48
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: KAT8, MOF, MYST1, PP7073
Authors : Ren, B., Peat, T.S.
Keywords : complex, lysine acetyltransferases, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.128 Å )
Citation :

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.

Baell, J.B.,Leaver, D.J.,Hermans, S.J.  et al.
(2018)  Nature  560 : 253 - 257

PubMed: 30069049
DOI: 10.1038/s41586-018-0387-5

Reaction

Chain : A
UniProt : Q9H7Z6 (KAT8_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+) 2.3.1.48 PubMed:10786633, PubMed:21217699, PubMed:22020126, PubMed:22547026, PubMed:26505788, PubMed:27382063, PubMed:27768893, PubMed:31794431, PubMed:33467728, PubMed:33657400, PubMed:16543150
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L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+) - PubMed:17189187, PubMed:19854137, PubMed:27292636, PubMed:37369679
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propanoyl-CoA + L-lysyl-[protein] = N(6)-propanoyl-L-lysyl- [protein] + CoA + H(+) - PubMed:29321206
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