Brand  (β version)

PDB ID: 6CSP

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
K Potassium ion PoSSuM
CL Chloride ion PoSSuM
FBM N-hydroxycyclohex-1-ene-1-carboxamide PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 6CSP   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with cyclohexenylhydroxamate
Release Data : 2018-05-30
Compound :
mol_id molecule chains
1 Hdac6 protein A,B
Source :
mol_id organism_scientific organism_common expression_system
1 Danio rerio  (taxid:7955) Zebrafish Escherichia coli  (taxid:562)
gene: hdac6
Authors : Porter, N.J., Christianson, D.W.
Keywords : Zinc hydrolase, tubulin deacetylase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.2370 Å )
Citation :

Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6.

Porter, N.J.,Wagner, F.F.,Christianson, D.W.
(2018)  Biochemistry  57 : 3916 - 3924

PubMed: 29775292
DOI: 10.1021/acs.biochem.8b00367

Reaction

Chain : A, B
UniProt : A7YT55 (A7YT55_DANRE)
Reaction: EC: Evidence:
Physiological Direction:
N(6)-acetyl-L-lysyl-[alpha-tubulin] + H2O = L-lysyl-[alpha- tubulin] + acetate - ARBA:ARBA00050910
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N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate - ARBA:ARBA00049136
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Cofactor: Evidence: Note:
Zn(2+) ECO:0000256 | ARBA:ARBA00001947
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