Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
VX O-ethylmethylphosphonic acid ester group
7PE 2-(2-(2-(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanol
FUC Alpha-L-fucose
NAG N-acetyl-D-glucosamine
Code : 6CQT
Header : HYDROLASE
Title : Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by (-) Stereoisomer of VX
Release Data : 2018-12-05
Compound :
mol_id molecule chains synonym
1 Acetylcholinesterase A,B AChE
ec: 3.1.1.7
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Homo sapiens  (taxid:9606)
gene: ACHE
Authors : Bester, S.M., Guelta, M.A., Pegan, S.D., Height, J.J.
Keywords : Hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.273 Å )
Citation :

Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6.

Bester, S.M.,Guelta, M.A.,Cheung, J.  et al.
(2018)  Chem. Res. Toxicol.  31 : 1405 - 1417

PubMed: 30462502
DOI: 10.1021/acs.chemrestox.8b00294

Chain : A, B
UniProt : P22303 (ACES_HUMAN)
Reaction : Acetylcholine + H(2)O = choline + acetate.