Brand  (β version)

PDB ID: 6CQH

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Ligands
Code Name Style Show Link
F8Y (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-8-ethyl-7-methyl-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one PoSSuM
SO4 Sulfate ion PoSSuM
ACT Acetate ion PoSSuM
GOL Glycerol PoSSuM
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Structure summary

Code : 6CQH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal Structure of the Human vaccinia-related kinase bound to a N-propynyl-N-ethyl-dihydropteridine inhibitor
Release Data : 2018-03-28
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase VRK1 A,B,C,D Vaccinia-related kinase 1
ec: 2.7.11.1
fragment: residues 3-364
mutation: K34A, K35A, E36A, E212A, K214A, E215A, E292A, K293A, K295A, K359A, K360A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: VRK1
expression_system_strain: BL21(DE3)
expression_system_variant: R3
expression_system_vector_type: plasmid
Authors : dos Reis, C.V., de Souza, G.P., Counago, R.M., Azevedo, A., Guimaraes, C., Mascarello, A., Gama, F., Ferreira, M., Massirer, K.B., Arruda, P., Edwards, A.M., Elkins, J.M., Structural Genomics Consortium (SGC)
Keywords : transferase, protein kinase domain, Structural Genomics, Structural Genomics Consortium, SGC, Transferase-Transferase Inhibitor Complex
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Crystal Structure of the Human vaccinia-related kinase bound to a N-propynyl-N-ethyl-dihydropteridine inhibitor

dos Reis, C.V.,de Souza, G.P.,Counago, R.M.  et al.
To Be Published 

Reaction

Chain : A, B, C, D
UniProt : Q99986 (VRK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:21543316
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:21543316
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