Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
F97 N-{2-(3,3-difluoropyrrolidin-1-yl)-6-[(3r)-pyrrolidin-3-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1h-pyrazolo[4,3-C]pyridin-6-amine
Code : 6CQF
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of HPK1 in complex an inhibitor G1858
Release Data : 2018-12-19
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase kinase kinase kinase 1 A HKP1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEKKK 1
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: MAP4K1, HPK1
expression_system_common: Fall armyworm
Authors : Wu, P., Lehoux, I., Mortara, K., Franke, Y., Chan, B.K., Wang, W.
Keywords : Protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.246 Å )
Citation :

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.

Wu, P.,Sneeringer, C.J.,Pitts, K.E.  et al.
(2019)  Structure  27 : 125 - 133.e4

PubMed: 30503777
DOI: 10.1016/j.str.2018.10.025

Chain : A
UniProt : Q92918 (M4K1_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.