Het-PDB Navi2 (PDB: 6CQ1)

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Ligands
Code	Name		Style	Show	Link
F8J	2-{6-({[2-(1h-indol-3-yl)ethyl]carbamothioyl}amino)-3-[(4-methylpiperazin-1-yl)methyl]-1h-indol-1-yl}-N-(propan-2-yl)acetamide				PoSSuM

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Download interaction data: 6CQ1

Code :

6CQ1 PDBj RCSB PDB PDBe

Header :

protein binding/inhibitor

Title :

BCL6 BTB domain in complex with 15a

Release Data :

2019-03-20

Compound :

mol_id	molecule	chains	synonym
1	B-cell lymphoma 6 protein	A,B	BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51
	mutation: C10Q; C69R; C86N; E101V

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: BCL6, BCL5, LAZ3, ZBTB27, ZNF51

Authors :

Linhares, B.M., Cheng, H., Xue, F., Cierpicki, T.

Keywords :

Protein protein inhibitor, PROTEIN BINDING, protein binding-inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 1.69921037793 Å )

Citation :

Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design.

Cheng, H.,Linhares, B.M.,Yu, W. et al.
(2018) J.Med.Chem. 61 : 7573 - 7588

PDB ID: 6CQ1