Brand  (β version)

PDB ID: 6CNX

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Ligands
Code Name Style Show Link
F87 (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-8-(3-methylbutyl)-5-(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5h)-one PoSSuM
SO4 Sulfate ion PoSSuM
ACT Acetate ion PoSSuM
GOL Glycerol PoSSuM
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Structure summary

Code : 6CNX   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase Inhibitor
Title : Crystal Structure of the Human vaccinia-related kinase 1 (VRK1) bound to an N-propynyl-N-isopentyl-dihydropteridin inhibitor
Release Data : 2018-04-04
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase VRK1 A,B,C,D Vaccinia-related kinase 1
ec: 2.7.11.1
fragment: residues 3-364
mutation: K34A, K35A, E36A, E212A, K214A, E215A, E292A, K293A, K295A, K359A, K360A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: VRK1
expression_system_strain: BL21(DE3)
expression_system_variant: R3
Authors : Counago, R.M., dos Reis, C.V., de Souza, G.P., Azevedo, A., Guimaraes, C., Mascarello, A., Gama, F., Ferreira, M., Massirer, K.B., Arruda, P., Edwards, A.M., Elkins, J.M., Structural Genomics Consortium (SGC)
Keywords : transferase, protein kinase domain, Structural Genomics, Structural Genomics Consortium, SGC, Transferase-Transferase Inhibitor Complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Crystal Structure of the Human Vaccinia-Related Kinase 1 (VRK1) bound to a N-propynyl-N-isopentil-dihydropteridine inhibitor

Counago, R.M.,dos Reis, C.V.,de Souza, G.P.  et al.
To Be Published 

Reaction

Chain : A, B, C, D
UniProt : Q99986 (VRK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:21543316
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:21543316
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