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Ligands
Code Name Style Show Link
F5Y 4-[5-(ethylsulfonyl)-2-methoxyphenyl]-2-methyl-6-(1-methyl-1h-pyrazol-4-yl)isoquinolin-1(2h)-one
Non-standard Residues
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Glycosylation
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Code : 6CKS   PDBj   RCSB PDB   PDBe
Header : GENE REGULATION/INHIBITOR
Title : Crystal Structure of BRD4 with QC4956
Release Data : 2018-05-02
Compound :
mol_id molecule chains synonym
1 Bromodomain-containing protein 4 A Protein HUNK1
fragment: UNP residues 44-168
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli K-12  (taxid:83333)
gene: BRD4, HUNK1
Authors : Hosfield, D.J.
Keywords : BRD4, Acetyllysine, epigenetics, GENE REGULATION-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.7200 Å )
Citation :

Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors.

Bennett, M.J.,Wu, Y.,Boloor, A.  et al.
(2018)  Bioorg. Med. Chem. Lett.  28 : 1811 - 1816

PubMed: 29657099
DOI: 10.1016/j.bmcl.2018.04.016

Chain : A
UniProt : O60885 (BRD4_HUMAN)
Reaction : -