Het-PDB Navi2 (PDB: 6CKC)

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Ligands
Code	Name		Style	Show	Link
F5J	7-[(5r)-5-C-phenyl-beta-D-ribofuranosyl]-7h-pyrrolo[2,3-D]pyrimidin-4-amine				PoSSuM

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Download interaction data: 6CKC

Code :

6CKC PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity

Release Data :

2018-05-16

Compound :

mol_id	molecule	chains	synonym
1	Protein arginine N-methyltransferase 5	A	72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs
	ec: 2.1.1.320

mol_id	molecule	chains	synonym
2	Methylosome protein 50	B	MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: PRMT5, HRMT1L5, IBP72, JBP1, SKB1

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: WDR77, MEP50, WD45, HKMT1069, Nbla10071

Authors :

Antonysamy, S.

Keywords :

Inhibitor, Complex, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.8000 Å )

Citation :

LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.

Bonday, Z.Q.,Cortez, G.S.,Grogan, M.J. et al.
(2018) ACS Med Chem Lett 9 : 612 - 617

Chain :

UniProt :

O14744 (ANM5_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L- homocysteine	2.1.1.320	PubMed:19011621, PubMed:21081503, PubMed:23071334
	-	PubMed:19011621, PubMed:21081503, PubMed:23071334

PDB ID: 6CKC