Brand  (β version)

PDB ID: 6CK3

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
F67 (3r)-3-methyl-5-[(pyrimidin-4-yl)amino]-2,3-dihydro-1h-isoindol-1-one PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6CK3   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE Inhibitor
Title : Co-crytsal Structure of MNK2 in Complex With an Inhibitor
Release Data : 2018-05-09
Compound :
mol_id molecule chains synonym
1 MAP kinase-interacting serine/threonine-protein kinase 2 A MAP kinase signal-integrating kinase 2,Mnk2
ec: 2.7.11.1
mutation: D228G
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:83333)
gene: MKNK2, GPRK7, MNK2
expression_system_strain: K-12
Authors : Han, Q.
Keywords : mnk2 inhibitor, TRANSFERASE-TRANSFERASE Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.

Reich, S.H.,Sprengeler, P.A.,Chiang, G.G.  et al.
(2018)  J. Med. Chem.  61 : 3516 - 3540

PubMed: 29526098
DOI: 10.1021/acs.jmedchem.7b01795

Reaction

Chain : A
UniProt : Q9HBH9 (MKNK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:11463832
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:11463832
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:11463832
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Zn(2+) - Binds 1 zinc ion per subunit.