Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
F4J 5-[(7h-purin-6-yl)amino]-1h-isoindol-1-one
ZN Zinc ion
Code : 6CJY
Header : TRANSFERASE/TRANSFERASE Inhibitor
Title : Crystal Structure of Mnk2-D228G in complex with Inhibitor
Release Data : 2018-05-09
Compound :
mol_id molecule chains synonym
1 MAP kinase-interacting serine/threonine-protein kinase 2 A MAP kinase signal-integrating kinase 2,Mnk2
ec: 2.7.11.1
mutation: D228G
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:83333)
gene: MKNK2, GPRK7, MNK2
expression_system_strain: K-12
Authors : Han, Q.
Keywords : MNK2 inhibitor, TRANSFERASE-TRANSFERASE Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 3.05 Å )
Citation :

Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.

Reich, S.H.,Sprengeler, P.A.,Chiang, G.G.  et al.
(2018)  J. Med. Chem.  61 : 3516 - 3540

PubMed: 29526098
DOI: 10.1021/acs.jmedchem.7b01795

Chain : A
UniProt : Q9HBH9 (MKNK2_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.