Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
DMS Dimethyl sulfoxide
EDO 1,2-ethanediol
F3D 4-[(2-{4-[(1e)-1-(1h-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide
Code : 6CHW
Header : nuclear protein/antagonist
Title : Estrogen Receptor Alpha Y537S covalently bound to antagonist H3B-5942.
Release Data : 2018-03-21
Compound :
mol_id molecule chains synonym
1 Estrogen receptor A ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
mutation: C381S, C417S, Y537S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ESR1, ESR, NR3A1
Authors : Larsen, N.A.
Keywords : Nuclear hormone receptor, covalent antagonist, activating mutation, breast cancer, NUCLEAR PROTEIN, nuclear protein-antagonist complex
Exp. method : X-RAY DIFFRACTION ( 1.89 Å )
Citation :

Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer.

Puyang, X.,Furman, C.,Zheng, G.Z.  et al.
(2018)  Cancer Discov  8 : 1176 - 1193

PubMed: 29991605
DOI: 10.1158/2159-8290.CD-17-1229

Chain : A
UniProt : P03372 (ESR1_HUMAN)
Reaction : -