Het-PDB Navi2 (PDB: 6CHW)

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Ligands
Code	Name	Link
DMS	Dimethyl sulfoxide	PoSSuM
EDO	1,2-ethanediol	PoSSuM
F3D	4-[(2-{4-[(1e)-1-(1h-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide	PoSSuM

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Download interaction data: 6CHW

Code :

6CHW PDBj RCSB PDB PDBe

Header :

nuclear protein/antagonist

Title :

Estrogen Receptor Alpha Y537S covalently bound to antagonist H3B-5942.

Release Data :

2018-03-21

Compound :

mol_id	molecule	chains	synonym
1	Estrogen receptor	A	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
	mutation: C381S, C417S, Y537S

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: ESR1, ESR, NR3A1

Authors :

Larsen, N.A.

Keywords :

Nuclear hormone receptor, covalent antagonist, activating mutation, breast cancer, NUCLEAR PROTEIN, nuclear protein-antagonist complex

Exp. method :

X-RAY DIFFRACTION ( 1.89 Å )

Citation :

Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer.

Puyang, X.,Furman, C.,Zheng, G.Z. et al.
(2018) Cancer Discov 8 : 1176 - 1193

PDB ID: 6CHW