Brand  (β version)

PDB ID: 6CAJ

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
C7B 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6CAJ   PDBj   RCSB PDB   PDBe
Header : TRANSLATION
Title : Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens
Release Data : 2018-04-11
Compound :
mol_id molecule chains synonym
1 Translation initiation factor eIF-2B subunit epsilon B,A eIF-2B GDP-GTP exchange factor subunit epsilon
mol_id molecule chains synonym
2 Translation initiation factor eIF-2B subunit gamma J,I eIF-2B GDP-GTP exchange factor subunit gamma
mol_id molecule chains synonym
3 Translation initiation factor eIF-2B subunit alpha H,G eIF-2B GDP-GTP exchange factor subunit alpha
mol_id molecule chains synonym
4 Translation initiation factor eIF-2B subunit beta C,D S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta
mol_id molecule chains synonym
5 Translation initiation factor eIF-2B subunit delta F,E eIF-2B GDP-GTP exchange factor subunit delta
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EIF2B5, EIF2BE
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EIF2B3
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EIF2B1, EIF2BA
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EIF2B2, EIF2BB
mol_id organism_scientific organism_common expression_system
5 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: EIF2B4, EIF2BD
Authors : Tsai, J.C., Miller-Vedam, L.E., Anand, A.A., Jaishankar, P., Nguyen, H.C., Renslo, A.R., Frost, A., Walter, P.
Keywords : guanine nucleotide exchange factor, translation initiation, ISRIB-bound, decameric complex, TRANSLATION
Exp. method : ELECTRON MICROSCOPY ( 2.8 Å )
Citation :

Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.

Tsai, J.C.,Miller-Vedam, L.E.,Anand, A.A.  et al.
(2018)  Science  359

PubMed: 29599213
DOI: 10.1126/science.aaq0939

Reaction

Chain : B, A
UniProt : Q13144 (EI2BE_HUMAN)
Reaction : -
Chain : J, I
UniProt : Q9NR50 (EI2BG_HUMAN)
Reaction : -
Chain : H, G
UniProt : Q14232 (EI2BA_HUMAN)
Reaction : -
Chain : C, D
UniProt : P49770 (EI2BB_HUMAN)
Reaction : -
Chain : F, E
UniProt : Q9UI10 (EI2BD_HUMAN)
Reaction : -