Het-PDB Navi2 (PDB: 6C9W)

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Ligands
Code	Name		Style	Show	Link
9PG	4-nitrophenyl alpha-D-galactopyranoside				PoSSuM
BNG	Nonyl beta-D-glucopyranoside				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6C9W

Code :

6C9W PDBj RCSB PDB PDBe

Header :

MEMBRANE PROTEIN

Title :

Crystal Structure of a ligand bound LacY/Nanobody Complex

Release Data :

2018-08-15

Compound :

mol_id	molecule	chains	synonym
1	Lactose permease	A	Lactose-proton symport
	fragment: Full mutation: G46W, G262W

mol_id	molecule	chains
2	Nanobody9047	B
	fragment: Full

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (strain K12) (taxid:83333)	Escherichia coli (taxid:562)
	strain: K12 gene: lacY, b0343, JW0334 expression_system_strain: C41 expression_system_vector_type: plasmid expression_system_plasmid: pT7-5

mol_id	organism_scientific	expression_system
2	Lama glama (taxid:9844)	Escherichia coli (taxid:562)
	expression_system_strain: WK6 expression_system_vector_type: Plasmid expression_system_plasmid: pMESy4

Authors :

Kumar, H., Finer-Moore, J.S., Jiang, X., Smirnova, I., Kasho, V., Pardon, E., Steyaert, J., Kaback, H.R., Stroud, R.M.

Keywords :

Membrane Protein

Exp. method :

X-RAY DIFFRACTION ( 3.0000 Å )

Citation :

Crystal Structure of a ligand-bound LacY-Nanobody Complex.

Kumar, H.,Finer-Moore, J.S.,Jiang, X. et al.
(2018) Proc. Natl. Acad. Sci. U.S.A. 115 : 8769 - 8774

Chain :

UniProt :

P02920 (LACY_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H(+)(in) + lactose(in) = H(+)(out) + lactose(out)	-	PubMed:1848449, PubMed:7000781, PubMed:7028742
H(+)(in) + lactose(in) = H(+)(out) + lactose(out)	right-to-left	PubMed:1848449, PubMed:7000781, PubMed:7028742
H(+)(in) + melibiose(in) = H(+)(out) + melibiose(out)	-	PubMed:1848449
H(+)(in) + melibiose(in) = H(+)(out) + melibiose(out)	right-to-left	PubMed:1848449

PDB ID: 6C9W