Brand  (β version)

PDB ID: 6C9C

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
EU1 (2r)-4-[4-{4-[(5-chloro-6-methoxypyridin-3-yl)methoxy]phenyl}-2-oxo-3,6-dihydropyridin-1(2h)-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide PoSSuM
F64 (2s)-4-[4-{4-[(5-chloro-6-methoxypyridin-3-yl)methoxy]phenyl}-2-oxo-3,6-dihydropyridin-1(2h)-yl]-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6C9C   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : Crystal structure of LpxC from Pseudomonas aeruginosa in complex with racemic ligand PT803
Release Data : 2019-03-13
Compound :
mol_id molecule chains synonym
1 UDP-3-O-acyl-N-acetylglucosamine deacetylase A UDP-3-O-acyl-GlcNAc deacetylase,UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase
ec: 3.5.1.108
fragment: PsaeA.00166.a.DG15,PsaeA.00166.a.DG15,PsaeA.00166.a.DG15,PsaeA.00166.a.DG15
mutation: M33V
Source :
mol_id organism_scientific expression_system
1 Pseudomonas aeruginosa (strain UCBPP-PA14)  (taxid:208963) Escherichia coli  (taxid:562)
strain: UCBPP-PA14
gene: lpxC, PA14_57260
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: PsaeA.00166.a.DG15
Authors : Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Keywords : inhibitor, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, SSGCID, LpxC, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

Crystal structure of LpxC from Pseudomonas aeruginosa in complex with ligand PT803

Delker, S.L.,Mayclin, S.J.,Phan, J.N.  et al.
to be published 

Reaction

Chain : A
UniProt : Q02H34 (LPXC_PSEAB)
Reaction: EC: Evidence:
Physiological Direction:
a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate 3.5.1.108 HAMAP-Rule:MF_00388
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