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Ligands
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CE3 (6r,7r)-3-(acetyloxymethyl)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-ethanoyl]amino]-8-oxo-5-thia-1-azabicy clo[4.2.0]oct-2-ene-2-carboxylic acid
SO4 Sulfate ion
Non-standard Residues
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Glycosylation
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Code : 6C79   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Conformational Changes in a Class A Beta lactamase that Prime it for Catalysis
Release Data : 2018-03-21
Compound :
mol_id molecule chains
1 Beta-lactamase Toho-1 A
ec: 3.5.2.6
fragment: residues 32-291
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: bla
Authors : Coates, L., Langan, P.S., Vandavasi, V.G., Cooper, S.J., Weiss, K.L., Ginell, S.L., Parks, J.M.
Keywords : HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.1 Å )
Citation :

Substrate Binding Induces Conformational Changes in a Class A Beta-lactamase That Prime It for Catalysis

Langan, P.S.,Vandavasi, V.G.,Cooper, S.J.  et al.
(2018)  Acs Catalysis  8 : 2428 - 2437

DOI: 10.1021/acscatal.7b04114

Chain : A
UniProt : Q47066 (BLT1_ECOLX)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE- ProRule:PRU10101
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