Het-PDB Navi2 (PDB: 6C1Q)

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Ligands
Code	Name		Style	Show	Link
9P2	1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine				PoSSuM

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACE	Acetyl group

Download interaction data: 6C1Q

Code :

6C1Q PDBj RCSB PDB PDBe

Header :

MEMBRANE PROTEIN

Title :

Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an allosteric antagonist NDT9513727

Release Data :

2018-05-30

Compound :

mol_id	molecule	chains	synonym
1	Soluble cytochrome b562, C5a anaphylatoxin chemotactic receptor 1 chimera	B	Cytochrome b-562,C5a anaphylatoxin chemotactic receptor, C5aR
	fragment: cytochrome (UNP residues 23-127) + C5a receptor (UNP residues 30-331) mutation: M29W, H124I, R128L

mol_id	molecule	chains
2	PMX53	L

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: C5AR1, C5AR, C5R1 expression_system_common: Fall armyworm expression_system_strain: SF9 expression_system_vector_type: baculovirus expression_system_plasmid: pFastbac

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Liu, H., Wang, L., Wei, Z., Zhang, C.

Keywords :

GPCR, MEMBRANE PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.9000 Å )

Citation :

Orthosteric and allosteric action of the C5a receptor antagonists.

Liu, H.,Kim, H.R.,Deepak, R.N.V.K. et al.
(2018) Nat. Struct. Mol. Biol. 25 : 472 - 481

Chain :

UniProt :

P0ABE7 (C562_ECOLX)

Cofactor:	Evidence:	Note:
Reaction :	-
heme b	-	Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule.

PDB ID: 6C1Q