Brand  (β version)

PDB ID: 6C06

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Ligands
Code Name Style Show Link
FI8 Fidaxomicin PoSSuM
MG Magnesium ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 6C06   PDBj   RCSB PDB   PDBe
Header : transcription/antibiotic
Title : Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin
Release Data : 2018-03-28
Compound :
mol_id molecule chains synonym
1 DNA-directed RNA polymerase subunit alpha A,B RNAP subunit alpha,RNA polymerase subunit alpha,Transcriptase subunit alpha
ec: 2.7.7.6
mol_id molecule chains synonym
2 DNA-directed RNA polymerase subunit beta C RNAP subunit beta,RNA polymerase subunit beta,Transcriptase subunit beta
ec: 2.7.7.6
mol_id molecule chains synonym
3 DNA-directed RNA polymerase subunit beta' D RNAP subunit beta',RNA polymerase subunit beta',Transcriptase subunit beta'
ec: 2.7.7.6
mol_id molecule chains synonym
4 DNA-directed RNA polymerase subunit omega E RNAP omega subunit,RNA polymerase omega subunit,Transcriptase subunit omega
ec: 2.7.7.6
mol_id molecule chains
5 RNA polymerase sigma factor SigA F
mol_id molecule chains
6 RNA polymerase-binding protein RbpA J
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
gene: rpoA, rpoA_1, CLD25_18970, ERS007661_01801, ERS007663_01917, ERS007665_01054, ERS007670_00938, ERS007672_03180, ERS007679_01858, ERS007688_02121, ERS007703_04392, ERS007720_00529, ERS007722_04215, ERS023446_02770, ERS024213_02470, ERS027644_00781, ERS027646_02177, ERS027652_00409, ERS027653_00362, ERS027654_02191, ERS027656_00886, ERS027659_01235, ERS027661_02549, ERS027666_01143, ERS124361_03550, SAMEA2682864_03600, SAMEA2683035_02863
mol_id organism_scientific expression_system
2 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
gene: rpoB, SAMEA2682864_01701
mol_id organism_scientific expression_system
3 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
gene: rpoC, rpoC_1, CLD25_03785, ERS007665_00591, ERS023446_00410, ERS031537_00289, ERS124361_01694, SAMEA2682864_01702
mol_id organism_scientific expression_system
4 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
gene: rpoZ, ERS007672_03979, ERS007703_04032, ERS007720_04749, ERS027652_00548, ERS027654_02543, ERS027656_03959, ERS124361_02246
mol_id organism_scientific expression_system
5 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
gene: sigA, hrdB_2, CLD25_14885, ERS007663_03246, ERS007679_00877, ERS007720_03380, ERS007722_02638, ERS023446_01203, ERS024213_00371, ERS024276_00878, ERS027644_01437, ERS027646_01351, ERS027653_01295, ERS027661_00252, ERS124361_02215, SAMEA2682864_02073, SAMEA2683035_01696
mol_id organism_scientific expression_system
6 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
gene: rbpA, CLD25_11245, ERS007670_01223, ERS007672_02518, ERS007679_02287, ERS007681_03389, ERS007688_02707, ERS007703_03544, ERS007720_03893, ERS007722_02881, ERS007731_02971, ERS007739_00749, ERS007741_03837, ERS023446_04025, ERS024213_00234, ERS024276_03708, ERS027644_04191, ERS027646_02841, ERS027652_02278, ERS027653_01824, ERS027654_04301, ERS027656_03007, ERS027659_00863, ERS027661_00907, ERS027666_04473, ERS031537_02569, ERS124361_01290, SAMEA2682864_00634, SAMEA2683035_00392
Authors : Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Keywords : initiation, antibiotic, switch region inhibitor, TRANSCRIPTION, transcription-antibiotic complex
Exp. method : ELECTRON MICROSCOPY ( 5.15 Å )
Citation :

Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.

Boyaci, H.,Chen, J.,Lilic, M.  et al.
(2018)  Elife  7

PubMed: 29480804
DOI: 10.7554/eLife.34823

Structure of Mycobacterium Tuberculosis RNAP Holo Enzyme/RbpA in closed clamp conformation

Darst, S.A.,Campbell, E.A.,Boyaci Selcuk, H.  et al.
To Be Published 

Reaction

Chain : A, B
UniProt : A0A045J8T1 (A0A045J8T1_MYCTX)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.6 ARBA:ARBA00024550, HAMAP-Rule:MF_00059
-
Chain : C
UniProt : V9Z879 (V9Z879_MYCTX)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.6 HAMAP-Rule:MF_01321, RuleBase:RU363031
-
Chain : D
UniProt : A0A045J9E2 (A0A045J9E2_MYCTX)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.6 ARBA:ARBA00024550, HAMAP-Rule:MF_01322, RuleBase:RU004279
-
Chain : E
UniProt : A0A0T9N9K3 (A0A0T9N9K3_MYCTX)
Reaction: EC: Evidence:
Physiological Direction:
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 2.7.7.6 ARBA:ARBA00024550, HAMAP-Rule:MF_00366
-
Chain : F
UniProt : A0A045HD00 (A0A045HD00_MYCTX)
Reaction : -
Chain : J
UniProt : A0A045IP01 (A0A045IP01_MYCTX)
Reaction : -