Brand  (β version)

PDB ID: 6BPT

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Ligands
Code Name Style Show Link
FE2 Fe (II) ion PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
F2Y 3,5-difluoro-L-tyrosine
Glycosylation
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Structure summary

Code : 6BPT   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of ferrous form of the uncrosslinked F2-Tyr157 human cysteine dioxygenase
Release Data : 2018-07-04
Compound :
mol_id molecule chains synonym
1 Cysteine dioxygenase type 1 A Cysteine dioxygenase type I, CDO-I
ec: 1.13.11.20
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CDO1
Authors : Liu, A., Li, J., Shin, I.
Keywords : Cysteine, Cys-Tyr cofactor, iron, unnatural amino acid, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.4020 Å )
Citation :

Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase.

Li, J.,Griffith, W.P.,Davis, I.  et al.
(2018)  Nat. Chem. Biol.  14 : 853 - 860

PubMed: 29942080
DOI: 10.1038/s41589-018-0085-5

Reaction

Chain : A
UniProt : Q16878 (CDO1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-cysteine + O2 = 3-sulfino-L-alanine + H(+) 1.13.11.20 PubMed:17135237
left-to-right
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:17135237
ECO:0000250 | UniProtKB:P60334
ECO:0000269 | PubMed:17135237
Binds 1 Fe(2+) cation per subunit. Zn(2+) can be used to a much lesser extent (PubMed:17135237). Ni(2+) can be used to a lesser extent (By similarity).