Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CL Chloride ion
DC 2'-deoxycytidine-5'-monophosphate
MG Magnesium ion
NA Sodium ion
DJJ 5'-O-[(R)-{[(R)-[(S)-chloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2'-deoxycytidine
Modified Residues
Code Name Link
2DA 2',3'-dideoxyadenosine-5'-monophosphate
Code : 6BEM
Header : TRANSFERASE/DNA
Title : Ternary complex crystal structure of DNA polymerase Beta with S-isomer of beta-gamma-CHCL-dCTP
Release Data : 2018-10-31
Compound :
mol_id molecule chains
1 Template strand T
mol_id molecule chains
2 Primer Strand P
mol_id molecule chains
3 Downstream Primer Strand D
mol_id molecule chains
4 DNA polymerase beta A
ec: 2.7.7.7,4.2.99.-
Source :
mol_id organism_scientific
1 Homo sapiens  (taxid:9606)
synthetic: yes
mol_id organism_scientific
2 Homo sapiens  (taxid:9606)
synthetic: yes
mol_id organism_scientific
3 Homo sapiens  (taxid:9606)
synthetic: yes
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: POLB
expression_system_strain: TAP56
expression_system_plasmid: pWL11
Authors : Batra, V.K., Wilson, S.H.
Keywords : DNA Polymerase Beta, Conformational Change, enzyme mechanism, LFER, TRANSFERASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 1.880 Å )
Citation :

Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.

Batra, V.K.,Oertell, K.,Beard, W.A.  et al.
(2018)  Biochemistry  57 : 3934 - 3944

PubMed: 29874056
DOI: 10.1021/acs.biochem.8b00418

To be published

Batra, V.K.,Wilson, S.H.
To Be Published 

Chain : A
UniProt : P06746 (DPOLB_HUMAN)
Reaction : Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).