Brand  (β version)

PDB ID: 6B97

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
MG Magnesium ion PoSSuM
CZY 6-chloro-1-methyl-N-{(1r)-1-[4-(trifluoromethyl)phenyl]ethyl}-1h-pyrazolo[3,4-D]pyrimidin-4-amine PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 6B97   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of PDE2 in complex with complex 9
Release Data : 2017-11-22
Compound :
mol_id molecule chains synonym
1 cGMP-dependent 3',5'-cyclic phosphodiesterase A,B Cyclic GMP-stimulated phosphodiesterase,cGSPDE
ec: 3.1.4.17
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PDE2A
Authors : Lu, J.
Keywords : phosphodiesterase 2, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.76 Å )
Citation :

The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.

Forster, A.B.,Abeywickrema, P.,Bunda, J.  et al.
(2017)  Bioorg. Med. Chem. Lett.  27 : 5167 - 5171

PubMed: 29113762
DOI: 10.1016/j.bmcl.2017.10.054

Reaction

Chain : A, B
UniProt : O00408 (PDE2A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'- phosphate + H(+) 3.1.4.17 PubMed:15938621, PubMed:29392776, PubMed:9210593
left-to-right PubMed:9210593
3',5'-cyclic GMP + H2O = GMP + H(+) - PubMed:15938621, PubMed:29392776, PubMed:9210593
left-to-right PubMed:9210593
3',5'-cyclic AMP + H2O = AMP + H(+) - PubMed:15938621, PubMed:29392776, PubMed:9210593
left-to-right PubMed:9210593
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:15938621
ECO:0000269 | PubMed:19828435
ECO:0000269 | PubMed:23899287
Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions.
Mg(2+) ECO:0000269 | PubMed:15938621
ECO:0000269 | PubMed:19828435
ECO:0000269 | PubMed:23899287
Binds 2 divalent metal cations per subunit. Site 2 has a preference for magnesium ions.