Brand  (β version)

PDB ID: 6B88

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Ligands
Code Name Style Show Link
CZD (8s,11s,14s)-14-{[(2s)-4-amino-2-{[2-(4-tert-butylphenyl)-4-methylpyrimidine-5-carbonyl]amino}butanoyl](methyl)amino}-3,18-bis(2-aminoethoxy)-N-[(2z)-2-iminoethyl]-11-methyl-10,13-dioxo-9,12-diazatricyclo[13.3.1.1~2,6~]icosa-1(19),2(20),3,5,15,17-hexaene-8-carboxamide PoSSuM
Non-standard Residues
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Structure summary

Code : 6B88   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE inhibitor
Title : E. coli LepB in complex with GNE0775 ((4S,7S,10S)-10-((S)-4-amino-2-(2-(4-(tert-butyl)phenyl)-4-methylpyrimidine-5-carboxamido)-N-methylbutanamido)-16,26-bis(2-aminoethoxy)-N-(2-iminoethyl)-7-methyl-6,9-dioxo-5,8-diaza-1,2(1,3)-dibenzenacyclodecaphane-4-carboxamide)
Release Data : 2018-10-10
Compound :
mol_id molecule chains synonym
1 Signal peptidase I A,B SPase I,Leader peptidase I
ec: 3.4.21.89
Source :
mol_id organism_scientific expression_system
1 Escherichia coli (strain K12)  (taxid:83333) Escherichia coli  (taxid:562)
strain: K12
gene: lepB, b2568, JW2552
Authors : Murray, J.M., Rouge, L.
Keywords : Signal peptidase, SBDD, antibiotic, HYDROLASE, HYDROLASE-HYDROLASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.4070 Å )
Citation :

Optimized arylomycins are a new class of Gram-negative antibiotics.

Smith, P.A.,Koehler, M.F.T.,Girgis, H.S.  et al.
(2018)  Nature  561 : 189 - 194

PubMed: 30209367
DOI: 10.1038/s41586-018-0483-6

Reaction

Chain : A, B
UniProt : P00803 (LEP_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. 3.4.21.89 -
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