Brand  (β version)

PDB ID: 6B76

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Ligands
Code Name Style Show Link
CVJ (1s,2s)-N-{4-[(1s)-1-(propanoylamino)ethyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6B76   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal Structure of human NAMPT in complex with NVP-LVR596
Release Data : 2018-10-03
Compound :
mol_id molecule chains synonym
1 Nicotinamide phosphoribosyltransferase A,B,C,D Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
ec: 2.4.2.12
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21  (taxid:511693)
gene: NAMPT, PBEF, PBEF1
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: pET41
Authors : Weihofen, W.A., Thigale, S.
Keywords : transferase
Exp. method : X-RAY DIFFRACTION ( 2.44 Å )
Citation :

Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors

Palacios, D.,Meredith, E.,Kawanami, T.  et al.
To Be Published 

Reaction

Chain : A, B, C, D
UniProt : P43490 (NAMPT_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
beta-nicotinamide D-ribonucleotide + diphosphate = 5-phospho- alpha-D-ribose 1-diphosphate + H(+) + nicotinamide 2.4.2.12 UniProtKB:Q99KQ4
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