Brand  (β version)

PDB ID: 6B5J

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Ligands
Code Name Style Show Link
CV4 N-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6B5J   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : TNNI3K complexed with a 4,6-diaminopyrimidine
Release Data : 2018-04-04
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase TNNI3K A,B,C,D Cardiac ankyrin repeat kinase,Cardiac troponin I-interacting kinase,TNNI3-interacting kinase
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Baculovirus  (taxid:10469)
gene: TNNI3K, CARK
expression_system_vector_type: baculovirus
expression_system_plasmid: pFASTBAC
Authors : Shewchuk, L.M., Philp, J.
Keywords : kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.9700 Å )
Citation :

4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors.

Philp, J.,Lawhorn, B.G.,Graves, A.P.  et al.
(2018)  J. Med. Chem.  61 : 3076 - 3088

PubMed: 29561151
DOI: 10.1021/acs.jmedchem.8b00125

Reaction

Chain : A, B, C, D
UniProt : Q59H18 (TNI3K_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12721663
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:12721663
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