Brand  (β version)

PDB ID: 6B4W

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Ligands
Code Name Style Show Link
CQ7 4-{[4-(cyclopentyloxy)-5-(2-methyl-1,3-benzoxazol-6-yl)-7h-pyrrolo[2,3-D]pyrimidin-2-yl]amino}-3-methoxy-N-methylbenzamide PoSSuM
CAC Cacodylate ion PoSSuM
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Structure summary

Code : 6B4W   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : TTK in Complex with Inhibitor
Release Data : 2017-10-25
Compound :
mol_id molecule chains synonym
1 Dual specificity protein kinase TTK A Phosphotyrosine picked threonine-protein kinase,PYT
ec: 2.7.12.1
fragment: UNP residues 515-795
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TTK, MPS1, MPS1L1
Authors : Delker, S., Chamberlain, P.P.
Keywords : Protein kinase, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.

Riggs, J.R.,Nagy, M.,Elsner, J.  et al.
(2017)  J. Med. Chem.  60 : 8989 - 9002

PubMed: 28991472
DOI: 10.1021/acs.jmedchem.7b01223

Reaction

Chain : A
UniProt : P33981 (TTK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.12.1 PubMed:29162720
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.12.1 PubMed:29162720
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ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.12.1 PubMed:29162720
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