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Ligands
Code Name Style Show Link
CQG Pyridin-4-ol
DMS Dimethyl sulfoxide
Non-standard Residues
Code Name Show
CME S,S-(2-hydroxyethyl)thiocysteine
Glycosylation
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Modification
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Code : 6B4Q   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/INHIBITOR
Title : Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with pyridin-4-ol
Release Data : 2018-10-03
Compound :
mol_id molecule chains synonym
1 Purine nucleoside phosphorylase A Inosine-guanosine phosphorylase
ec: 2.4.2.1
Source :
mol_id organism_scientific organism_common expression_system
1 Schistosoma mansoni  (taxid:6183) Blood fluke Escherichia coli  (taxid:469008)
expression_system_strain: Lemo21 (DE3)
expression_system_plasmid: pOPINS3C
Authors : Faheem, M., Neto, J.B., Collins, P., Pearce, N.M., Valadares, N.F., Bird, L., Pereira, H.M., Delft, F.V., Barbosa, J.A.R.G.
Keywords : Purine Nucleoside Phosphorylase, TRANSFERASE, TRANSFERASE-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.600 Å )
Citation :

Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with pyridine-4-ol

Faheem, M.,Neto, J.B.,Collins, P.  et al.
To Be Published 

Chain : A
UniProt : A0A0U3AGT1 (A0A0U3AGT1_SCHMA)
Reaction: EC: Evidence:
Physiological Direction:
2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + guanine 2.4.2.1 ARBA:ARBA00023929
-
2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1- phosphate + hypoxanthine 2.4.2.1 ARBA:ARBA00023950
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guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine 2.4.2.1 ARBA:ARBA00023970
-
inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine 2.4.2.1 ARBA:ARBA00023918
-