Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
7PR Praseodymium triacetate
CJV Methyl {(1s,2r)-2-[(S)-cyano[1-({1-[4-({1-[4-(dimethylamino)butanoyl]azetidin-3-yl}sulfonyl)phenyl]azetidin-3-yl}methyl)piperidin-4-yl](3-fluorophenyl)methyl]cyclopentyl}carbamate
Code : 6B41
Header : PROTEIN BINDING/INHIBITOR
Title : Menin bound to M-525
Release Data : 2018-01-24
Compound :
mol_id molecule chains
1 Menin A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MEN1, SCG2
Authors : Stuckey, J.A.
Keywords : Covalent Inhibitor, MEN1 syndrome, leukemia, PROTEIN BINDING-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.6100 Å )
Citation :

Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.

Xu, S.,Aguilar, A.,Xu, T.  et al.
(2018)  Angew. Chem. Int. Ed. Engl.  57 : 1601 - 1605

PubMed: 29284071
DOI: 10.1002/anie.201711828

Chain : A
UniProt : O00255 (MEN1_HUMAN)
Reaction : -