Brand  (β version)

PDB ID: 6B3T

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Ligands
Code Name Style Show Link
CJ7 8-fluoro-5-methyl-3-{[2-(piperidin-1-yl)ethyl]sulfanyl}-5h-[1,2,4]triazino[5,6-B]indole PoSSuM
COA Coenzyme a PoSSuM
NA Sodium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6B3T   PDBj   RCSB PDB   PDBe
Header : transferase/transferase inhibitor
Title : Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a 1,2,4-triazino[5,6b]indole-3-thioether inhibitor analogue 39b
Release Data : 2018-04-04
Compound :
mol_id molecule chains synonym
1 N-acetyltransferase Eis A Aminoglycoside N-acetyltransferase,Enhanced intracellular survival protein,Protein-lysine N-acetyltransferase
ec: 2.3.1.-
mutation: C204A
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)  (taxid:83332) Escherichia coli BL21(DE3)  (taxid:469008)
strain: ATCC 25618 / H37Rv
gene: eis, Rv2416c, MTCY253.04
Authors : Gajadeera, C.S., Hou, C., Garneau-Tsodikova, S., Ngo, H.X., Tsodikov, O.V.
Keywords : TRANSFERASE, tuberculosis, aminoglycoside, resistance, transferase-transferase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis.

Ngo, H.X.,Green, K.D.,Gajadeera, C.S.  et al.
(2018)  ACS Infect Dis  4 : 1030 - 1040

PubMed: 29601176
DOI: 10.1021/acsinfecdis.8b00074

Reaction

Chain : A
UniProt : P9WFK7 (EIS_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] - PubMed:22547814
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