Het-PDB Navi2 (PDB: 6B31)

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Ligands
Code	Name		Style	Show	Link
CFJ	(3s)-N~1~-(3-chloro-4-cyanophenyl)-N~5~-(1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)-3-methylpentanediamide				PoSSuM

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Download interaction data: 6B31

Code :

6B31 PDBj RCSB PDB PDBe

Header :

signaling protein/agonist

Title :

Structure of RORgt in complex with a novel inverse agonist 2

Release Data :

2018-08-01

Compound :

mol_id	molecule	chains	synonym
1	Nuclear receptor ROR-gamma	A,B	Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: RORC, NR1F3, RORG, RZRG

Authors :

Skene, R.J., Hoffman, I.

Keywords :

Complex, inverse agonist, Nuclear Hormone Receptor, SIGNALING PROTEIN, signaling protein-agonist complex

Exp. method :

X-RAY DIFFRACTION ( 3.1800 Å )

Citation :

Identification of novel quinazolinedione derivatives as ROR gamma t inverse agonist.

Fukase, Y.,Sato, A.,Tomata, Y. et al.
(2018) Bioorg. Med. Chem. 26 : 721 - 736

PDB ID: 6B31