Het-PDB Navi2 (PDB: 6B2P)

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Ligands
Code	Name		Style	Show	Link
CJJ	5-{5-chloro-4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}thiophene-2-sulfonamide				PoSSuM

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Download interaction data: 6B2P

Code :

6B2P PDBj RCSB PDB PDBe

Header :

TRANSFERASE/INHIBITOR

Title :

Dual Inhibition of the Essential Protein Kinases A and B in Mycobacterium tuberculosis

Release Data :

2018-02-14

Compound :

mol_id	molecule	chains
1	Serine/threonine-protein kinase PknB	A
	ec: 2.7.11.1

Source :

mol_id	organism_scientific	expression_system
1	Mycobacterium tuberculosis (taxid:1773)	Escherichia coli (taxid:562)
	gene: pknB

Authors :

Zuccola, H.J.

Keywords :

kinase, drug design, tuberculosis, TRANSFERASE-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 3.01 Å )

Citation :

Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions.

Wang, T.,Bemis, G.,Hanzelka, B. et al.
(2017) ACS Med Chem Lett 8 : 1224 - 1229

Chain :

UniProt :

P9WI80 (PKNB_MYCTO)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.1	-
	-	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.1	-
	-	-

PDB ID: 6B2P