Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
AMP Adenosine monophosphate
CG7 5-{[6-chloro-5-(2'-hydroxy[1,1'-biphenyl]-4-yl)-1h-imidazo[4,5-B]pyridin-2-yl]oxy}-2-methylbenzoic acid
STU Staurosporine
Modified Residues
Code Name Link
GLC Alpha-D-glucopyranose
SEP Phosphoserine
TPO Phosphothreonine
Code : 6B2E
Header : TRANSFERASE
Title : Structure of full length human AMPK (a2b2g1) in complex with a small molecule activator SC4.
Release Data : 2018-04-25
Compound :
mol_id molecule chains synonym
1 5'-AMP-activated protein kinase catalytic subunit alpha-2 A AMPK subunit alpha-2,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase
ec: 2.7.11.1,2.7.11.27,2.7.11.31
mol_id molecule chains synonym
2 5'-AMP-activated protein kinase subunit beta-2 B AMPK subunit beta-2
mol_id molecule chains synonym
3 5'-AMP-activated protein kinase subunit gamma-1 C AMPKg
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: PRKAA2, AMPK, AMPK2
expression_system_strain: Rosetta (DE3)
expression_system_plasmid: pETDuet-1
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: PRKAB2
expression_system_strain: Rosetta (DE3)
expression_system_plasmid: pRSFDuet-1
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: PRKAG1
expression_system_strain: Rosetta (DE3)
expression_system_plasmid: pETDuet-1
Authors : Ngoei, K.R.W., Langendorf, C.G., Ling, N.X.Y., Hoque, A., Johnson, S., Camerino, M.C., Walker, S.R., Bozikis, Y.E., Dite, T.A., Ovens, A.J., Smiles, W.J., Jacobs, R., Huang, H., Parker, M.W., Scott, J.W., Rider, M.H., Kemp, B.E., Foitzik, R.C., Baell, J.B., Oakhill, J.S.
Keywords : Phosphorylated, Active, Heterotrimer, Kinase., TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 3.80 Å )
Citation :

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4.

Ngoei, K.R.W.,Langendorf, C.G.,Ling, N.X.Y.  et al.
(2018)  Cell Chem Biol  25 : 728 - 737.e9

PubMed: 29657085
DOI: 10.1016/j.chembiol.2018.03.008

Chain : A
UniProt : P54646 (AAPK2_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.
ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate.
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate.
Chain : B
UniProt : O43741 (AAKB2_HUMAN)
Reaction : -
Chain : C
UniProt : P54619 (AAKG1_HUMAN)
Reaction : -