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Ligands
Code Name Style Show Link
C8Y (2s,5r)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carbonitrile
CL Chloride ion
Non-standard Residues
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Glycosylation
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Code : 6B22   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE Inhibitor
Title : Crystal structure OXA-24 beta-lactamase complexed with WCK 4234 by co-crystallization
Release Data : 2018-08-01
Compound :
mol_id molecule chains synonym
1 Beta-lactamase A Beta-lactamase OXA-33,Betalactamase OXA24,Carbapenem-hydrolyzing beta-lactamase OXA-40,Carbapenem-hydrolyzing oxacillinase,Carbapenem-hydrolyzing oxacillinase OXA-40,Carbapenemase OXA-24,Class D beta-lactamase OXA-40,OXA24 B-lactamase,Oxa40
fragment: UNP residues 32-275
Source :
mol_id organism_scientific expression_system
1 Acinetobacter baumannii  (taxid:470) Escherichia coli  (taxid:562)
gene: blaOXA-33, bla-OXA-40, blaOXA-24, blaOXA-40, oxa-24, oxa40
Authors : van den Akker, F., Nguyen, N.Q.
Keywords : Inhibitor, complex, HYDROLASE, HYDROLASE-HYDROLASE Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.9300 Å )
Citation :

Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.

Papp-Wallace, K.M.,Nguyen, N.Q.,Jacobs, M.R.  et al.
(2018)  J. Med. Chem.  61 : 4067 - 4086

PubMed: 29627985
DOI: 10.1021/acs.jmedchem.8b00091

Chain : A
UniProt : Q8RLA6 (Q8RLA6_ACIBA)
Reaction : -