Brand  (β version)

PDB ID: 6B1Q

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
1AP 2,6-diaminopurine nucleotide
CJ1 7-(2-deoxy-5-O-phosphono-beta-D-erythro-pentofuranosyl)-7h-pyrrolo[2,3-D]pyrimidine-2,4-diol
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6B1Q   PDBj   RCSB PDB   PDBe
Header : DNA BINDING PROTEIN/DNA
Title : Hydrogen Bonding Complementary, not size complementarity is key in the formation of the double helix
Release Data : 2018-09-19
Compound :
mol_id molecule chains
1 Reverse transcriptase A
ec: 2.7.7.49
fragment: Catalytic fragment (UNP residues 683-937)
mol_id molecule chains
2 DNA (5'-D(*CP*TP*TP*AP*TP*(CJ1)P*(CJ1)P*(CJ1))-3') B
mol_id molecule chains
3 DNA (5'-D(P*(1AP)P*(1AP)P*(1AP)P*AP*TP*AP*AP*G)-3') G
Source :
mol_id organism_scientific organism_common expression_system
1 Moloney murine leukemia virus  (taxid:11801) MoMLV Escherichia coli  (taxid:562)
mol_id organism_scientific
2 Escherichia coli  (taxid:562)
synthetic: yes
mol_id organism_scientific
3 Escherichia coli  (taxid:562)
synthetic: yes
Authors : Singh, I., Georgiadis, M.M.
Keywords : Protein-DNA, AEGIS, unnatural base pair, host-guest system, DNA BINDING PROTEIN, DNA BINDING PROTEIN-DNA complex
Exp. method : X-RAY DIFFRACTION ( 1.9000 Å )
Citation :

"Skinny" and "Fat" DNA: Two New Double Helices.

Hoshika, S.,Singh, I.,Switzer, C.  et al.
(2018)  J. Am. Chem. Soc.  140 : 11655 - 11660

PubMed: 30148365
DOI: 10.1021/jacs.8b05042

Reaction

Chain : A
UniProt : P03355 (POL_MLVMS)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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Endonucleolytic cleavage to 5'-phosphomonoester. 3.1.26.4 PROSITE-ProRule:PRU00408
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