PDB ID: 6B1O
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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C8S | (2s)-2-amino-1-[(1s,3s,5s)-3-(aminomethyl)-2-azabicyclo[3.1.0]hexan-2-yl]-2-[(1r,3r,5s,7s)-3,5-dihydroxytricyclo[3.3.1.1~3,7~]decan-1-yl]ethan-1-one | PoSSuM |
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NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose |
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Download interaction data: 6B1O
Structure summary
Code : | 6B1O PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE Inhibitor | ||||||||||||
Title : | The structure of DPP4 in complex with Vildagliptin Analog | ||||||||||||
Release Data : | 2017-09-27 | ||||||||||||
Compound : |
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Authors : | Scapin, G. | ||||||||||||
Keywords : | Diabetes, DPP4 inhibitors, covalent inhibitors, HYDROLASE, HYDROLASE-HYDROLASE Inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.9100 Å ) | ||||||||||||
Citation : |
A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice.
Berger, J.P.,SinhaRoy, R.,Pocai, A.
et al.
PubMed: 30815539 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P27487 (DPP4_HUMAN) | ||||||||
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