PDB ID: 6B0Z
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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NDP | Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate | PoSSuM | |||
C81 | (4r)-4-[(1s)-1-fluoroethyl]-3-[2-({(1s)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl}amino)pyrimidin-4-yl]-1,3-oxazolidin-2-one | PoSSuM | |||
FLC | Citrate anion | PoSSuM |
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Download interaction data: 6B0Z
Structure summary
Code : | 6B0Z PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | IDH1 R132H mutant in complex with IDH305 | ||||||||||||
Release Data : | 2017-11-08 | ||||||||||||
Compound : |
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Source : |
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Authors : | Xie, X., Kulathila, R. | ||||||||||||
Keywords : | Isocitrate dehydrogenase, Rossmann fold, NADPH, inhibitor, OXIDOREDUCTASE | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.3340 Å ) | ||||||||||||
Citation : |
Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor.
Cho, Y.S.,Levell, J.R.,Liu, G.
et al.
PubMed: 29057061 |
Reaction
Chain : | A, C, B, D | |||||||||
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UniProt : | O75874 (IDHC_HUMAN) | |||||||||
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