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Ligands
Code Name Style Show Link
CA Calcium ion
C8G 1-[3-(4-{[(4,5-dichloro-2-hydroxyphenyl)amino]acetyl}piperazin-1-yl)azetidin-1-yl]propan-1-one
GDP Guanosine-5'-diphosphate
Non-standard Residues
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Code : 6B0V   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Crystal Structure of small molecule ARS-107 covalently bound to K-Ras G12C
Release Data : 2018-05-16
Compound :
mol_id molecule chains synonym
1 GTPase KRas A,B K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
fragment: UNP residues 1-169
mutation: G12C, C51S, C80L, C118S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: KRAS, KRAS2, RASK2
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pJexpress411
Authors : Hansen, R., Peters, U., Babbar, A., Chen, Y., Feng, J., Janes, M.R., Li, L.-S., Ren, P., Liu, Y., Zarrinkar, P.P.
Keywords : small GTPase domain, covalent inhibitor bound, switch II pocket, GDP bound, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.2900 Å )
Citation :

The reactivity-driven biochemical mechanism of covalent KRASG12Cinhibitors.

Hansen, R.,Peters, U.,Babbar, A.  et al.
(2018)  Nat. Struct. Mol. Biol.  25 : 454 - 462

PubMed: 29760531
DOI: 10.1038/s41594-018-0061-5

Chain : A, B
UniProt : P01116 (RASK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate 3.6.5.2 PubMed:20949621
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