PDB ID: 6B0V
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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CA | Calcium ion | PoSSuM | |||
C8G | 1-[3-(4-{[(4,5-dichloro-2-hydroxyphenyl)amino]acetyl}piperazin-1-yl)azetidin-1-yl]propan-1-one | PoSSuM | |||
GDP | Guanosine-5'-diphosphate | PoSSuM |
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Download interaction data: 6B0V
Structure summary
Code : | 6B0V PDBj RCSB PDB PDBe | ||||||||||||
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Header : | SIGNALING PROTEIN | ||||||||||||
Title : | Crystal Structure of small molecule ARS-107 covalently bound to K-Ras G12C | ||||||||||||
Release Data : | 2018-05-16 | ||||||||||||
Compound : |
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Authors : | Hansen, R., Peters, U., Babbar, A., Chen, Y., Feng, J., Janes, M.R., Li, L.-S., Ren, P., Liu, Y., Zarrinkar, P.P. | ||||||||||||
Keywords : | small GTPase domain, covalent inhibitor bound, switch II pocket, GDP bound, SIGNALING PROTEIN | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.2900 Å ) | ||||||||||||
Citation : |
The reactivity-driven biochemical mechanism of covalent KRASG12Cinhibitors.
Hansen, R.,Peters, U.,Babbar, A.
et al.
PubMed: 29760531 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P01116 (RASK_HUMAN) | ||||||||
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