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Ligands
Code Name Style Show Link
C6J [2-(1-methylpyridin-2-yl)-1-phosphono-ethyl]phosphonic acid
MG Magnesium ion
EDO 1,2-ethanediol
Non-standard Residues
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Glycosylation
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Code : 6B04   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of CfFPPS2, a lepidopteran type-II farnesyl diphosphate synthase, complexed with [2-(1-methylpyridin-2-yl)-1-phosphono-ethyl]phosphonic acid (inhibitor 1b)
Release Data : 2017-12-13
Compound :
mol_id molecule chains synonym
1 Farnesyl diphosphate synthase A,B,C CfFPPS2, type-II farnesyl diphosphate synthase
ec: 2.5.1.-
fragment: UNP residues 57-397
Source :
mol_id organism_scientific organism_common expression_system
1 Choristoneura fumiferana  (taxid:7141) Spruce budworm moth Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_strain: Rosetta2 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Picard, M.-E., Cusson, M., Shi, R.
Keywords : juvenile hormone, farnesyl diphosphate synthase, inhibitor design, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.8300 Å )
Citation :

Structural characterization of a lepidopteran type-II farnesyl diphosphate synthase from the spruce budworm, Choristoneura fumiferana: Implications for inhibitor design.

Picard, M.E.,Nisole, A.,Beliveau, C.  et al.
(2017)  Insect Biochem. Mol. Biol.  92 : 84 - 92

PubMed: 29183817
DOI: 10.1016/j.ibmb.2017.11.011

Chain : A, B, C
UniProt : Q1XAB1 (Q1XAB1_CHOFU)
Reaction : -