Het-PDB Navi2 (PDB: 6AZW)

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Ligands
Code	Name		Style	Show	Link
C51	(2r)-N-(4-cyanophenyl)-2-[cis-4-(quinolin-4-yl)cyclohexyl]propanamide				PoSSuM

Non-standard Residues
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Download interaction data: 6AZW

Code :

6AZW PDBj RCSB PDB PDBe

Header :

oxidoreductase/oxidoreductase inhibitor

Title :

IDO1/FXB-001116 crystal structure

Release Data :

2018-03-21

Compound :

mol_id	molecule	chains	synonym
1	Indoleamine 2,3-dioxygenase 1	A,B	IDO-1,Indoleamine-pyrrole 2,3-dioxygenase
	ec: 1.13.11.52

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: IDO1, IDO, INDO

Authors :

Lewis, H.A., Lammens, A., Steinbacher, S.

Keywords :

IDO1/FXB-001116 crystal structure, oxidoreductase-oxidoreductase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.780 Å )

Citation :

Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.

Nelp, M.T.,Kates, P.A.,Hunt, J.T. et al.
(2018) Proc. Natl. Acad. Sci. U.S.A. 115 : 3249 - 3254

Chain :

A, B

UniProt :

P14902 (I23O1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
D-tryptophan + O2 = N-formyl-D-kynurenine	1.13.11.52	PubMed:17671174
D-tryptophan + O2 = N-formyl-D-kynurenine	-	PubMed:17671174
L-tryptophan + O2 = N-formyl-L-kynurenine	1.13.11.52	PubMed:17671174
L-tryptophan + O2 = N-formyl-L-kynurenine	-	PubMed:17671174

PDB ID: 6AZW