Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
C5V (1s,2s)-N-{4-[(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)methyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide
Code : 6AZJ
Header : TRANSFERASE
Title : Crystal Structure of human NAMPT in complex with NVP-LQN520
Release Data : 2018-09-12
Compound :
mol_id molecule chains synonym
1 Nicotinamide phosphoribosyltransferase A,B Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
ec: 2.4.2.12
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: NAMPT, PBEF, PBEF1
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET47b
Authors : Weihofen, W.A., Thigale, S.
Keywords : Transferase
Exp. method : X-RAY DIFFRACTION ( 2.53 Å )
Citation :

Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors

Palacios, D.,Meredith, E.,Kawanami, T.  et al.
To Be Published 

Chain : A, B
UniProt : P43490 (NAMPT_HUMAN)
Reaction : Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate.