Het-PDB Navi2 (PDB: 6AYD)

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Ligands
Code	Name		Style	Show	Link
C2J	N-[6-(4-hydroxyphenyl)-2h-indazol-3-yl]cyclopropanecarboxamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 6AYD

Code :

6AYD PDBj RCSB PDB PDBe

Header :

Transferase/Transferase Inhibitor

Title :

Pim1 complexed with N-(6-(4-hydroxyphenyl)-1H-indazol-3-yl)cyclopropanecarboxamide

Release Data :

2017-12-27

Compound :

mol_id	molecule	chains
1	Serine/threonine-protein kinase pim-1	A
	ec: 2.7.11.1 fragment: UNP residues 1-312 mutation: R250G

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PIM1

Authors :

Shewchuk, L.M., Henley, Z.A.

Keywords :

Kinase, Transferase-Transferase Inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 3.0 Å )

Citation :

From PIM1 to PI3K delta via GSK3 beta : Target Hopping through the Kinome.

Henley, Z.A.,Bax, B.D.,Inglesby, L.M. et al.
(2017) ACS Med Chem Lett 8 : 1093 - 1098

Chain :

UniProt :

P11309 (PIM1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394, PubMed:37797010
	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:37797010
	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000269 \| PubMed:15525646 ECO:0000269 \| PubMed:15657054 ECO:0000269 \| PubMed:15808862	-

PDB ID: 6AYD