Brand  (β version)

PDB ID: 6AY2

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Ligands
Code Name Style Show Link
C1G N~1~-[(2s)-1-amino-5-(carbamoylamino)pentan-2-yl]-N'~1~-[(1r)-1-(thiophen-3-yl)ethyl]cyclobutane-1,1-dicarboxamide PoSSuM
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Structure summary

Code : 6AY2   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Structure of CathB with covalently linked Compound 28
Release Data : 2017-12-27
Compound :
mol_id molecule chains synonym
1 Cathepsin B A,B APP secretase, APPS, Cathepsin B1
ec: 3.4.22.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CTSB, CPSB
Authors : Kiefer, J.R., Steinbacher, S.
Keywords : protease, covalent, inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.6000 Å )
Citation :

Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.

Wei, B.,Gunzner-Toste, J.,Yao, H.  et al.
(2018)  J. Med. Chem.  61 : 989 - 1000

PubMed: 29227683
DOI: 10.1021/acs.jmedchem.7b01430

Reaction

Chain : A, B
UniProt : P07858 (CATB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C- terminal dipeptides. 3.4.22.1 PubMed:12220505, PubMed:3972105
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